Derby County take on Stoke City at Pride Park in the Sky Bet Championship.
Promotion-chasing Brentford travel north to take on Hull City at the KCOM Stadium in the Sky Bet Championship. Will the Bees be able to contain Hull's highly rated forward Jarrod Bowen?
Action from the Premier League as Leicester City host Chelsea at the King Power Stadium.
Nuno Espirito Santo's Wolves travel to Old Trafford to face Manchester United. The sides shared the spoils in a 1-1 draw when they met in the league at Molineux.
Mikel Arteta's Arsenal face a tricky test as they travel to take on Sean Dyche's Burnley at Turf Moor in the Premier League. The Gunners have won on their last four visits to this ground.
Managerial rivals Jose Mourinho and Pep Guardiola go head-to-head once more as Tottenham Hotspur welcome Manchester City to the Tottenham Hotspur Stadium in the Premier League.