Newport County take on Salford City in the second semi-final from the Checkatrade Trophy
Tottenham host RB Leipzig in the first leg of their Champions League Round of 16 tie. The Tottenham Hotspur Stadium has seen more goals than any other venue in this season's UCL.
Atalanta face Valencia in the first leg of their UEFA Champions League Round of 16 tie at the San Siro. This will be the first ever encounter between the two sides.
Derby County welcome Fulham to Pride Park in the Sky Bet Championship.
Chelsea and Tottenham go head-to-head in the Premier League as they meet at Stamford Bridge.
Thomas Frank's promotion-chasing Brentford welcome Blackburn to Griffin Park in the Sky Bet Championship. Bradley Dack struck early on to help Rovers to a 1-0 win in the reverse game.
Italy take on Scotland in the six nations with both teams looking for their first win in this years tournament.
Wales take on France in this six nations clash as France look to extend their unbeaten run in their pursuit on the Grand Slam.
Sutton United host Barrow in the Vanarama National League at Borough Sports Ground.
Brendan Rodgers's Leicester City welcome Premier League champions Manchester City to the King Power Stadium. Pep Guardiola's side ran out 3-1 winners when the sides met earlier this season.
England take on Ireland in this six nations clash at Twickenham. Can England end Irelands unbeaten start in the battle of the Farrells!
Mikel Arteta's Arsenal welcome another of his former clubs - Everton - to the Emirates Stadium in the Premier League. A tightly fought reverse fixture at Goodison ended 0-0.